At Biogen, our mission is clear – we are pioneers in neuroscience. Biogen discovers, develops, and delivers worldwide innovative therapies for people living with serious neurological and neurodegenerative diseases. Together, our employees create, commercialize, and manufacture transformative therapies for our patient population.
We at Biogen are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients who we serve. We are focused on strengthening our foundation to advance our overall Diversity, Equity and Inclusion (DE&I) strategy and, most importantly, ensure all our employees feel included.
As an intern or co-op at Biogen, you can expect to be placed on a real project, under the guidance of experience professionals and subject matter experts who are invested in your career and academic growth. We also ensure that you have plenty of opportunities to build your network, learn more about our organization through weekly lunch and learns led by leaders from across the company, and join us for several fun events.
This position is for a 6-month Co-op lasting from January – June 2022
Computational chemistry group is seeking a co-op who will perform molecular dynamic simulations on RNA-small molecule complexes.
Targeting RNAs with small molecules offers opportunities to therapeutically modulate numerous cellular processes, including those linked to ‘undruggable’ protein targets. A good understanding of RNA – small molecule interactions is key to targeting RNAs. Riboswitches are relatively well-characterized structurally, and several structures of small molecule-bound riboswitches are available. In this role you will perform the following, including but not limited to:
- Perform Molecular Dynamics simulations to characterize small molecule interactions with RNA and delineate them in comparison to small molecule protein interactions.
- Compare forcefields across different software to find the best alternative for RNA simulations
- Write reports and give presentations to internal/external audience
- Publish the project work in peer-reviewed scientific journals.
- Experience in running molecular dynamic simulations and data analysis applying statistical methods
- Working proficiency of computational chemistry software suite such as: Amber, Schrodinger, VMD
- Expertise in Python, Shell programming and Linux/Unix system
- Knowledge of RNA structures, receptor (protein/RNA)-ligand interactions is a plus
To participate in the Biogen Co-op Program, students must meet the following eligibility criteria:
- Legal authorization to work in the U.S.
- At least 18 years of age prior to the scheduled start date
- Be currently enrolled in an accredited college or university
A Ph.D. student in computational chemistry or a relevant field is preferred.