The Scientist will join the Early Target Biology group at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early stage therapeutic targets. The position will utilize and develop cellular biological, genome engineering, and functional genomics to screen and validate tumor intrinsic targets that confer resistance to targeted- and immuno-therapies.
The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment and aid the advancement of the next wave of targets into preclinical drug development. The candidate will be expected to effectively collaborate with colleagues across Discovery Oncology including the exploratory pharmacology, drug discovery and translational research groups. The successful candidate will demonstrate clear and professional verbal and written communication skills and will be capable of communicating these results across multidisciplinary teams. The position requires the ability to design, iterate, and lead several key project initiatives and demonstrate critical thinking to challenge self and others.
Qualifications and key responsibilities
o A B.S. with a minimum of 7 years of experience, or an M.S. with a minimum of 5 years of academic/industrial experience
o Demonstrated independence in experimental design, execution, data analysis, and troubleshooting is required.
o Strong scientific and hands-on experience using a wide range of cellular and molecular biology techniques, including tissue culture, flow cytometry, western blotting, ELISA, use of genetic perturbation techniques (eg shRNA, CRISPR-mediated genome editing), qRT-PCR, cell proliferation assays, molecular cloning techniques, and lentivirus generation and transduction is a requirement.
o Experience in forward and reverse genetic screening followed by target validation studies to elucidate mechanistic biology and oncogenic SAR is strongly preferred.
o Experience in cancer genome data mining through use of desktop tools/interfaces and public databases (e.g., CBIO, TCGA, CCLE, Genepattern etc) is highly desirable.
o Proficiency in utilizing software such as Graph Pad, Microsoft office etc. for data analysis and figure generation is required.
o Ability to lead, design, and execute on project initiatives and operates to a High Standard. Attention to detail with excellent organizational and record keeping skills is a requirement.
o Excellent interpersonal skills with the ability to interact effectively with people, internally and externally, is required.
o This position is located in Cambridge, MA. There will be less than 10% travel.