Position: Research: Computational Biologist – Greg Cooper Lab
Position Type: Full-Time
Note: In-person work is preferred, remote candidates will be considered
HudsonAlpha Institute for Biotechnology is a non-profit facility with the mission to use biotechnology and basic biological research to make important discoveries, improve human health, stimulate economic development and inspire young people to seek careers in science. Located in Cummings Research Park in Huntsville, Alabama, one of the world’s leading science and technology business parks, the four-story, 270,000 square foot building contains state-of-the-art laboratories for biological research and development in the areas of genomics, genetics and personalized medicine.
Dr. Cooper’s lab focuses on the analytical challenges and opportunities presented by affordable, routine sequencing of human genomes, motivated by the long-term goal of understanding how our genomes shape our lives. Research topics include development of functional annotations of human genomes, analyses of genetic effects on gene expression, and discovery of variants that contribute to rare disease, including clinically diagnostic variants, with whole genome sequencing. The Cooper lab is comprised of a group of highly motivated scientists that function as a collaborative unit.
The Computational Biologist will analyze and maneuver data generated from both internal and external sources, create pipelines and reporting software, and aid other scientists in the group with a variety of computational tasks. The Computational Biologist enables the rapid, incremental analysis required to best process and interpret the large amount of data generated in genomics laboratories. The candidate will have access to state-of-the-art genomic technologies and compute infrastructure, as well as expertise in applying these approaches to understand human health and disease. In addition, the successful Computational Biologist will exhibit genuine curiosity and enthusiasm for discovery-based computational genomics research and will enjoy working as part of a cohesive, driven research team. While in-person work is preferred, candidates who require or prefer remote work will be considered.
JOB SPECIFIC TASKS
- Develop, maintain, document, and automate analytical pipelines for manipulating genomics datasets and interpret results appropriately to ensure accuracy and reliability of those pipelines
- Collaborate on projects with others in the research team, including other computational biologists, experimental biologists, and genomic analysts to plan and implement tools, which may include the development of new algorithms and the evaluation and implementation of existing algorithms
- Develop software to enable reporting and organization of data via databases or other storage and organization mechanisms for both internal and external use
- Write reports and contribute to resulting research papers
- Other duties as assigned
EDUCATION AND REQUIRED SKILLS EXPERIENCE
Education and Experience:
- Master’s degree in bioinformatics, computational biology, biology, biostatistics, or related field; bachelor’s degree with relevant experience may be considered
- Knowledge of current bioinformatics approaches and databases
- Experience with multiple programming languages and computational environments, including UNIX-style operating systems, command-line interfaces, R, Perl/Python or similar, and SQL or other database software
- Preference for candidates with experience in tools and processes enabling reproducible research in high-performance computing environments, such as: version control, cloud computing, containers, RESTful interfaces, web frameworks, or workflow management systems
- Background in statistics and quantitative data analysis, as demonstrated through previous work or academic experience
- Experience with and knowledge of biological sciences, especially genetics and molecular biology
- Excellent communication skills and ability to work with others to accomplish goals
- Excellent programming skills and ability to maneuver large data sets
- Ability to document work performed, especially in support of publishing scientific results and to enable software re-use and robustness
Physical Demands/Environmental Factors/Mental Functions
ADA Requirements The physical demands, work environment factors, and mental functions described below are representative of those that must be met by an employee to successfully perform the essential function of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Disclaimer – All job requirements are subject to possible revision to reflect changes in the position requirements or to reasonably accommodate individuals with disabilities. Some requirements may exclude individuals who pose a threat or risk to the health and safety of themselves or other employees. This job description in no way states or implies that these are the only duties which will be required in this position. Employees will be required to follow other job-related duties as requested by their supervisor/manager (within guidelines and compliance with Federal and State Laws). Continued employment remains on an “at-will” basis.
- Must be able to remain in a stationary position (sit or stand) for prolonged periods (50% of the time).
- Occasionally move about the office (accessing files/storage, office equipment, computers and other office productivity devices, attending meetings, etc.).
- Constant use of common office equipment (e.g. computers, mobile devices, calculators, copiers, scanners).
- Close vision and the ability to adjust focus.
- Communicate in person and over the telephone.
- Must be able to work at a PC monitor for most of the workday
- Perform work in an indoor office environment with controlled temperature.
- Tolerate moderate noise level (i.e. business office with computers, phone, and printers, light traffic).
- Continuous mental and visual attention.
- Communicate effectively, both orally and in writing, in the English language.
- Analyze and solve problems.
- Learn and apply new skills and information.
- Read and interpret data, information, and documents.
It is the policy of HudsonAlpha Institute for Biotechnology, in accordance with all applicable laws, to recruit, hire, train, and promote persons in all job titles without regard to race, color, religion, sex, age, national origin, disability, genetic information, sexual orientation, veteran status, or any other basis prohibited by applicable law.